Title page 14-3-3 Proteins Interact with Neurofilament Protein-L (NF-L) and Regulate Dynamic Assembly of Neurofilaments
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14-3-3 Proteins Interact with Neurofilament Protein-L (NF-L) and Regulate Dynamic Assembly of Neurofilaments Linqing Miao, Junlin Teng, Jiqiang Lin, Xianzhi Liao and Jianguo Chen 2 * 1 The State Key Laboratory of Bio-membrane and Membrane Bio-engineering, and The Key Laboratory of Cell Proliferation and Differentiation of Ministry of Education, College of Life Sciences, Peking University, Beijing 100871, China 2 The Center for Theoretical Biology, Peking University, Beijing 100871, China
منابع مشابه
14-3-3 proteins interact with neurofilament protein-L and regulate dynamic assembly of neurofilaments.
Neurofilament protein-L (NF-L) is the core component of neurofilaments. Recent studies indicate that the NF-L mutations reported in human Charcot-Marie-Tooth (CMT) disease lead to the formation of NF-L aggregates and result in axon degeneration of motor and sensory neurons, which are thought to be the cause of CMT disease type 2E. In the present study, we investigated the dynamic regulation of ...
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Neurofilaments are neuronal intermediate filaments that play an important role in the growth and maintenance of large myelinated axons. Mammalian neurofilaments are composed of three polypeptide subunits, designed as NF-L, NF-M, and NF-H, all of which are phosphorylated. Here, we demonstrate by several criteria that neurofilament polypeptides are also modified by an abundant type of intracellul...
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تاریخ انتشار 2012